Water → HCID 178513170, compound

HRID 1289753Notes

Reaction equation

HRID 1289753 reaction equation
[Cl:1][C:2]1[CH:11]=[CH:10][C:5]([C:6]([NH:8][NH2:9])=[O:7])=[CH:4][CH:3]=1.S(O)(O)(=O)=O.C[NH:18][C:19](=[NH:21])S.[OH-].[Na+].O>CO>[C:19]([NH:9][NH:8][C:6](=[O:7])[C:5]1[CH:10]=[CH:11][C:2]([Cl:1])=[CH:3][CH:4]=1)(=[NH:18])[NH2:21]

Participants

6

Reactant 4

HCID 962WaterHCID 108164-ChlorobenzohydrazideHCID 14798Sodium HydroxideHCID 178485225HCID 178485225, compound

Product 1

HCID 178513170HCID 178513170, compoundYield 104.7%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
60 °C

Procedure

The synthesis was carried out according to the method of Example 1-(1). 4-Chlorobenzoic acid hydrazide (34.8 g), methylisothiourea sulfate (115.4 g), sodium hydroxide (17.1 g), water (440 ml) and methanol (700 ml) were used as reagents. The mixture was stirred for 4 days at 60° C. to give 45.4 g of a pale-brown solid which was a mixture of a hydrazide compound and the objective compound.

Sources & evidence

ORD record
ord-3d761e524d6a482c880699c727a262cb
Source dataset
uspto-grants-1998_05
Patent number
US05750545

Reaction notes

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