1,2-Dichloroethane → 1-Naphthalenecarboxylic acid, 4-chloro-, methyl ester

HRID 1289770Notes

Reaction equation

HRID 1289770 reaction equation
[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5]([C:12]([OH:14])=[O:13])=[CH:4][CH:3]=1.Cl[CH2:16]CCl.S(=O)(=O)(O)O>CO>[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5]([C:12]([O:14][CH3:16])=[O:13])=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 111,2-DichloroethaneHCID 1118Sulfuric AcidHCID 127491434-Chloronaphthalene-1-carboxylic acid

Product 1

HCID 222616151-Naphthalenecarboxylic acid, 4-chloro-, methyl esterYield 96%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The synthesis method of Example 7-(1) was applied. The compound (1.93g) obtained in (2) above, 1,2-dichloroethane (50 ml), methanol (25 ml) and concentrated sulfuric acid (1.8 ml) were used as reagents to give 1.99 g of a red-brown solid (yield 96%).

Sources & evidence

ORD record
ord-3452d2e606cd4a66b73d4eb547aa1650
Source dataset
uspto-grants-1998_05
Patent number
US05750545

Reaction notes

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