Hydrochloric Acid → HCID 70195928, compound

HRID 128978Notes

Reaction equation

HRID 128978 reaction equation
[CH3:1][N:2]1[C@@H:6]([CH2:7][C:8]2[CH:13]=[CH:12][C:11]([N+:14]([O-])=O)=[CH:10][CH:9]=2)[CH2:5][O:4][C:3]1=[O:17].[ClH:18]>C(O)C.[Pd]>[ClH:18].[CH3:1][N:2]1[C@@H:6]([CH2:7][C:8]2[CH:13]=[CH:12][C:11]([NH2:14])=[CH:10][CH:9]=2)[CH2:5][O:4][C:3]1=[O:17]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 53932626(4S)-3-Methyl-4-[(4-nitrophenyl)methyl]-2-oxazolidinone

Product 1

HCID 70195928HCID 70195928, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A suspension of the product from step (a) (4.0 g) and 10% w/w Pd/C (0.20 g) in a mixture of ethanol (70 ml) and dil. HCl (2N aqu. HCl (12 ml) +water (55 ml)) was hydrogenated at 45 psi for 1 hour. The mixture was filtered through Hyflo and the filtrate evaporated in vacuo to give the desired product as a foam.

Workup

  1. filtrationThe mixture was filtered through Hyflo
  2. customthe filtrate evaporated in vacuo

Sources & evidence

ORD record
ord-8d313d3abccd466b9c1d63df722a0998
Source dataset
uspto-grants-1995_11
Patent number
US05466699

Reaction notes

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