Hydrochloric Acid → HCID 10538453, Verbindung

HRID 1289785Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1289785
[NH2:1][C:2]1[N:6]=[C:5]([CH2:7][C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[NH:4][N:3]=1.[OH-].[Na+].[CH3:16][N:17]=[C:18]=[S:19].Cl>O1CCCC1>[NH2:1][C:2]1[N:3]([C:18]([NH:17][CH3:16])=[S:19])[N:4]=[C:5]([CH2:7][C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=2)[N:6]=1

Komponenten

6

Edukt 4

HCID 313Hydrochloric AcidHCID 11167Methyl isothiocyanateHCID 14798Sodium HydroxideHCID 11166975-benzyl-1H-1,2,4-triazol-3-amine

Produkt 1

HCID 10538453HCID 10538453, VerbindungAusbeute 40 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

The synthesis method of Example 7-(3) was applied. The compound (6.17 g) obtained in (1) above, a 0.77N aqueous sodium hydroxide solution (40 ml), methyl isothiocyanate (2.86 g) and tetrahydrofuran (40 ml) were used as reagents and the mixture was stirred at room temperature for 17 hours. 2N Hydrochloric acid (19 ml) was added to neutralize the mixture. The resulting crystals were collected by filtration and washed with hexane-ethyl acetate to give 3.55 g of white powdery crystals (yield 40%).

Aufarbeitung

  1. filtrationThe resulting crystals were collected by filtration
  2. washwashed with hexane-ethyl acetate

Quellen und Nachweise

ORD-Eintrag
ord-2295b0b5ffd34b24bf29fd08147e08b6
Quelldatensatz
uspto-grants-1998_05
Patentnummer
US05750545

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