Methanol, 1,1-diethoxy-, 1-acetate → HCID 18922213, compound

HRID 1289801Notes

Reaction equation

HRID 1289801 reaction equation
[NH2:1][C:2]1[N:6]([C:7]([NH:9][CH2:10][CH2:11][CH3:12])=[S:8])[N:5]=[C:4]([C:13]2[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][CH:14]=2)[N:3]=1.[C:20](OC(OCC)OCC)(=O)C>>[Cl:19][C:16]1[CH:15]=[CH:14][C:13]([C:4]2[N:3]=[C:2]3[N:1]=[CH:20][N:9]([CH2:10][CH2:11][CH3:12])[C:7](=[S:8])[N:6]3[N:5]=2)=[CH:18][CH:17]=1

Participants

3

Reactant 2

HCID 84166Methanol, 1,1-diethoxy-, 1-acetateHCID 18922220HCID 18922220, compound

Product 1

HCID 18922213HCID 18922213, compoundYield 71.5%

Procedure

The synthesis method of Example 55 was applied. The compound (280 mg) obtained in Example 44 and diethoxymethyl acetate (6.0 g) were used as reagents. The mixture was reacted at 100° C. for 2.5 hours to give 207 mg of white crystals (yield 71%).

Workup

  1. customThe synthesis method of Example 55
  2. customThe mixture was reacted at 100° C. for 2.5 hours

Sources & evidence

ORD record
ord-525a34ba25ce46a1902249b40b83d708
Source dataset
uspto-grants-1998_05
Patent number
US05750545

Reaction notes

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