反应详情

To a solution of 25 mg of amine prepared in Example 11 and 0.05 mL of DIPEA in 0.5 mL of methylene chloride was added 12 mg of methyl chloroformate. After 1.5 h in a sealed vial, the volatiles were evaporated under a stream of nitrogen and the residue was purified on a 1 mm preparative silica gel plate eluted with ethyl acetate to afford 20 mg of title compound. Mass spec (NH3 /CI): 476 (M+1).

1. customAfter 1.5 h in a sealed vial, the volatiles were evaporated under a stream of nitrogen
2. customthe residue was purified on a 1 mm preparative silica gel plate
3. washeluted with ethyl acetate