反应详情

A solution of 1.0 g of 2-chloro-5-(1-tetrazolyl)benzoic acid from Step A in 25 mL of methanol was saturated with HCl (gas) and stirred for 20 h. The solution was concentrated in vacuo, diluted with water and extracted twice with ether. The organic layers were washed with a portion of brine, combined, dried over sodium sulfate and evaporated to afford 1.0 g of title compound.

1. concentrationThe solution was concentrated in vacuo
2. additiondiluted with water
3. extractionextracted twice with ether
4. washThe organic layers were washed with a portion of brine
5. dry with materialdried over sodium sulfate
6. customevaporated