5-Bromothiazole → HCID 18922352, compound
Reaction equation
[CH:1]([C:3]1[CH:4]=[C:5](B(O)O)[CH:6]=[CH:7][C:8]=1[O:9][CH3:10])=[O:2].Br[C:15]1[S:19][CH:18]=[N:17][CH:16]=1>>[CH3:10][O:9][C:8]1[CH:7]=[CH:6][C:5]([C:15]2[S:19][CH:18]=[N:17][CH:16]=2)=[CH:4][C:3]=1[CH:1]=[O:2]Participants
3
Procedure
The title compound was prepared by employing the method described in Example 111, Step A with (3-formyl-4-methoxyphenyl)boronic acid and the known 5-bromothiazole (E. J. Trybulski and H. J. Brabander, U.S. Pat. No. 4,990,520, 1991). NMR (400 MHz, CDCl3): δ 10.48 (s, 1H), 8.76 (s, 1H), 8.04 (s, 1H), 8.01 (d, 1H, J=2 Hz), 7.75 (dd, 1H, J=9,2 Hz), 7.05 (d, 1H, J=9 Hz), 3.97 (s, 3H). Mass spectrum (NH3 /CI): 220 (M+1).
Sources & evidence
- ORD record
- ord-8c53b0479ac14738b5a581509650d17a
- Source dataset
- uspto-grants-1998_05
- Patent number
- US05750549
Reaction notes
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