反应详情

Exposure of the product from Step B above to 2.2 equivalents of HCl in methanol/ethyl ether followed by evaporation provided the title compound. NMR (400 MHz, CD3OD): δ 8.81 (d, 1H, J=5 Hz), 8.64 (td, 1H, J=8,1 Hz), 8.35 (d, 1H, J=8 Hz), 8.06 (dd, 1H, J=9,2 Hz), 8.02-7.96 (m, 2H), 7.45 (dd, 2H, J=9,5 Hz), 7.34 (d, 1H, J=9 Hz), 7.20 (t, 2H, J=9 Hz), 4.31 (d, 1H, J=13 Hz), 4.15 (d, 1H, J=13 Hz), 4.03-3.96 (m, 1H), 3.90 (dd, 1H, J=9,8 Hz), 3.85 (s, 3H), 3.64 (s, 3H), 3.46 (quartet, 1H, J=9 Hz), 2.54-2.38 (m, 2H), 2.25-2.14 (m, 1H), 2.08-1.96 (m, 1H).