反应详情

Exposure of the product from Step B above to 2.2 equivalents of HCl in methanol/ethyl ether followed by evaporation provided the title compound. NMR (400 MHz, CD3OD): δ 9.15 (d, 1H, J=2 Hz), 8.85 (dt, 1H, J=8,2 Hz), 8.80 (d, 1H, J=5 Hz), 8.04 (dd, 1H, J=8,5 Hz), 7.92 (dd, 1H, J=9,2 Hz), 7.82 (d, 1H, J=2 Hz), 7.43 (dd, 2H, J=9,5 Hz), 7.26 (d, 1H, J=9 Hz), 7.21 (t, 2H, J=9 Hz), 4.30 (d, 1H, J=13 Hz), 4.14 (d, 1H, J=13 Hz), 3.99-3.92 (m, 1H), 3.90 (dd, 1H, J=9,8 Hz), 3.80 (s, 3H), 3.63 (s, 3H), 3.42 (quartet, 1H, J=8 Hz), 2.52-2.38 (m, 2H), 2.22-2.12 (m, 1H), 2.07-1.96 (m, 1H).