反应详情

Exposure of the product from Step A above to 2.5 equivalents of HCl in methanol/ethyl ether followed by evaporation provided the title compound. NMR (400 MHz, CD3OD): δ 8.83 (d, 2H, J=7 Hz), 8.36(d, 2H, J=7 Hz), 8.14(dd, 1H, J=9,2 Hz), 8.03(d, 1H, J=2 Hz), 7.43 (dd, 2H, J=9,5 Hz), 7.30 (d, 1H, J=9 Hz), 7.21 (t, 2H, J=9 Hz), 4.31 (d, 1H, J=13 Hz), 4.16 (d, 1H, J=13 Hz), 4.00-3.94 (m, 1H), 3.90 (dd, 1H, J=9,8 Hz), 3.85 (s, 3H), 3.63 (s, 3H), 3.46-3.38 (m, 1H), 2.52-2.38 (m, 2H), 2.22-2.12 (m, 1H), 2.08-1.96 (m, 1H).