Pyridine → HCID 135488221, compound

HRID 1290047Notes

Reaction equation

HRID 1290047 reaction equation
[C:1]([C:4]1[C:5]([OH:14])=[C:6]2[C:10](=[CH:11][CH:12]=1)[NH:9][C:8](=[O:13])[CH2:7]2)(=O)[CH3:2].[N:15]1C=CC=CC=1>CN(C=O)C>[CH3:2][C:1]1[C:4]2[CH:12]=[CH:11][C:10]3[NH:9][C:8](=[O:13])[CH2:7][C:6]=3[C:5]=2[O:14][N:15]=1

Participants

4

Reactant 2

HCID 1049PyridineHCID 10442534HCID 10442534, compound

Product 1

HCID 135488221HCID 135488221, compoundYield 34%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

The procedure described in Example 33d was followed with the oxime acetate obtained in step c (0.334 g, 1.35 mmol) and pyridine (0.55 mL, 6.75 mmol) in DMF (25 mL). After work-up, the residue was purified by silica gel flash chromatography (50→75% EtOAc-hexanes) to give the title compound (0.086 g, 34%) as a white solid.

Workup

  1. customAfter work-up, the residue was purified by silica gel flash chromatography (50→75% EtOAc-hexanes)

Sources & evidence

ORD record
ord-3697a19a5ab249cf8cf7dde3180bcb78
Source dataset
uspto-grants-1998_05
Patent number
US05750542

Reaction notes

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