Pyridine → HCID 10058448, compound

HRID 1290049Notes

Reaction equation

HRID 1290049 reaction equation
[C:1]([C:4]1[CH:12]=[C:11]2[C:7]([CH2:8][C:9](=[O:13])[NH:10]2)=[CH:6][C:5]=1[OH:14])(=O)[CH3:2].[N:15]1C=CC=CC=1>CN(C=O)C>[CH3:2][C:1]1[C:4]2[CH:12]=[C:11]3[NH:10][C:9](=[O:13])[CH2:8][C:7]3=[CH:6][C:5]=2[O:14][N:15]=1

Participants

4

Reactant 2

HCID 1049PyridineHCID 10081257HCID 10081257, compound

Product 1

HCID 10058448HCID 10058448, compoundYield 12%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

The procedure described in Example 33d was followed with the oxime acetate obtained in step c (2.75 g, 10.97 mmol) and pyridine (8.9 mL, 109.7 mmol) in DMF (110 m). After concentration in vacuo, the residue was purified by silica gel flash chromatography (2% MeOH--CH2Cl,) to give the title compound (0.245 g, 12%) as a pastel yellow solid.

Workup

  1. concentrationAfter concentration in vacuo
  2. customthe residue was purified by silica gel flash chromatography (2% MeOH--CH2Cl,)

Sources & evidence

ORD record
ord-674f1ec5485c4587a8b09a8cca9eaba3
Source dataset
uspto-grants-1998_05
Patent number
US05750542

Reaction notes

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