Methylamine → HCID 19373123, compound

HRID 129005Notes

Reaction equation

HRID 129005 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:9]=[C:10]3[N:14]([C:15]=2[CH2:16][C:17]([O:19]CC)=O)[C:13]2[CH:22]=[CH:23][CH:24]=[CH:25][C:12]=2[NH:11]3)=[CH:4][CH:3]=1.[CH3:26][NH2:27]>CO>[CH3:26][NH:27][C:17](=[O:19])[CH2:16][C:15]1[N:14]2[C:10]([NH:11][C:12]3[CH:25]=[CH:24][CH:23]=[CH:22][C:13]=32)=[N:9][C:8]=1[C:5]1[CH:6]=[CH:7][C:2]([CH3:1])=[CH:3][CH:4]=1

Participants

4

Reactant 2

HCID 6329MethylamineHCID 19373120HCID 19373120, compound

Product 1

HCID 19373123HCID 19373123, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

2 g of ethyl 2-(4-methylphenyl)-9H-imidazo[1,2-a]benzimidazole-3-acetate in 60 ml of methanol are treated with 60 ml of liquid methylamine, while stirring the mixture at room temperature for 16 h. The solvent is evaporated under reduced pressure. The residue is washed with water and recrystallized twice from N,N-dimethylformamide. 0.8 g of compound is finally isolated. Melting point: 303°-308° C. (decomposition).

Workup

  1. customThe solvent is evaporated under reduced pressure
  2. washThe residue is washed with water
  3. customrecrystallized twice from N,N-dimethylformamide

Sources & evidence

ORD record
ord-3199f77b998d44fcb987d7378f08097f
Source dataset
uspto-grants-1995_11
Patent number
US05466706

Reaction notes

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