HRID1290132

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID6344

Dichloromethane

CH2Cl2

结构：CC(=O)OC1C(=O)C2(C)C(O)CC(C)C(CO)(OC(C)=O)C2C(OC(=O)c2ccccc2)C2(O)CC(OC(=O)C(O)C(NC(=O)c3ccccc3)c3ccccc3)C(C)=C1C2(C)C

HCID24728718

未命名化合物

PRODUCTS

生成物

HCID18522661

未命名化合物

HCID24728718

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID180

Acetone

C3H6O

PROCEDURE

实验过程

No paclitaxol was found in the foreruns of experiments conducted with methylene chloride and acetone as cosolvents at 10 mole %. About half of the paclitaxol (0.0242%) with a purification factor of 16 was recovered from the silica column in a methylene chloride cosolvent experiment (TAXC-36C). A SCF CO2 /acetone experiment (TAXC-37C) yielded less paclitaxol (0.0147% with a purification factor of 15) from the silica column.

WORKUP

后处理

customAbout half of the paclitaxol (0.0242%) with a purification factor of 16 was recovered from the silica column in a methylene chloride cosolvent experiment (TAXC-36C)

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-152c35789825441fa93579b53f0d3d0c
来源数据集: uspto-grants-1998_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05750709
来源说明: uspto-grants-1998_05

反应 SMILES

[CH3:1][CH:2]1[C:7]([O:10][C:11]([CH3:13])=[O:12])([CH2:8][OH:9])[CH:6]2[CH:14]([O:53][C:54]([C:56]3[CH:61]=[CH:60][CH:59]=[CH:58][CH:57]=3)=[O:55])[C:15]3([OH:52])[C:20]([CH3:22])([CH3:21])[C:19]([CH:23]([O:26][C:27]([CH3:29])=[O:28])[C:24](=[O:25])[C:5]2([CH3:62])[CH:4]([OH:63])[CH2:3]1)=[C:18]([CH3:30])[CH:17]([O:31][C:32]([CH:34]([OH:51])[CH:35]([NH:42][C:43]([C:45]1[CH:50]=[CH:49][CH:48]=[CH:47][CH:46]=1)=[O:44])[C:36]1[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=1)=[O:33])[CH2:16]3.C(Cl)Cl>CC(C)=O>[C:11](=[O:12])=[O:10].[CH3:6][C:7]([CH3:2])=[O:10].[CH3:1][CH:2]1[C:7]([O:10][C:11]([CH3:13])=[O:12])([CH2:8][OH:9])[CH:6]2[CH:14]([O:53][C:54]([C:56]3[CH:57]=[CH:58][CH:59]=[CH:60][CH:61]=3)=[O:55])[C:15]3([OH:52])[C:20]([CH3:21])([CH3:22])[C:19]([CH:23]([O:26][C:27]([CH3:29])=[O:28])[C:24](=[O:25])[C:5]2([CH3:62])[CH:4]([OH:63])[CH2:3]1)=[C:18]([CH3:30])[CH:17]([O:31][C:32]([CH:34]([OH:51])[CH:35]([NH:42][C:43]([C:45]1[CH:46]=[CH:47][CH:48]=[CH:49][CH:50]=1)=[O:44])[C:36]1[CH:37]=[CH:38][CH:39]=[CH:40][CH:41]=1)=[O:33])[CH2:16]3