HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dichloromethane → Acetone cardice
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | HCID 24728718 | HCID 24728718 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | Acetone cardice | HCID 18522661 | — |
| Product | HCID 24728718 | HCID 24728718 | — |
Reaction Steps
No paclitaxol was found in the foreruns of experiments conducted with methylene chloride and acetone as cosolvents at 10 mole %. About half of the paclitaxol (0.0242%) with a purification factor of 16 was recovered from the silica column in a methylene chloride cosolvent experiment (TAXC-36C). A SCF CO2 /acetone experiment (TAXC-37C) yielded less paclitaxol (0.0147% with a purification factor of 15) from the silica column.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05750709 |
| Source dataset | uspto-grants-1998_05 |
| ORD ID | ord-152c35789825441fa93579b53f0d3d0c |
| Source note | uspto-grants-1998_05 |