Water → HCID 11746175, compound

HRID 1290136Notes

Reaction equation

HRID 1290136 reaction equation
Br[CH2:2][C:3](Br)([C:5]1[CH:10]=[CH:9][C:8]([F:11])=[CH:7][C:6]=1[F:12])[CH3:4].[NH:14]1[CH:18]=[N:17][CH:16]=[N:15]1.O>CN(C=O)C>[N:14]1([CH2:2][C:3]([C:5]2[CH:10]=[CH:9][C:8]([F:11])=[CH:7][C:6]=2[F:12])=[CH2:4])[CH:18]=[N:17][CH:16]=[N:15]1

Participants

5

Reactant 3

HCID 962WaterHCID 92571H-1,2,4-TriazoleHCID 15232458HCID 15232458, compound

Product 1

HCID 11746175HCID 11746175, compoundYield 30%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

5 g (15.9 mmol) of 1,2-dibromo-2-(2,4-difluorophenyl) propane VIII and 3.3 g (48 mmol) of 1,2,4-triazole in DMF was refluxed for 15 hours. The reaction mixture was cooled down to room temperature, water (40 mL) was added and product was extracted with EtOAc (2×50 mL). The EtOAc phase was washed with water and dried (Na2SO4). Evaporation of the solvent under reduced pressure and purification of the residue on a silica gel column with ethyl acetate as the eluent, furnished the title compound (1.05 g, 30%).

Workup

  1. extractionproduct was extracted with EtOAc (2×50 mL)
  2. washThe EtOAc phase was washed with water
  3. dry with materialdried (Na2SO4)
  4. customEvaporation of the solvent
  5. customunder reduced pressure and purification of the residue on a silica gel column with ethyl acetate as the eluent

Sources & evidence

ORD record
ord-c4378b2f43e4447585acb7fbec34da1d
Source dataset
uspto-grants-1998_05
Patent number
US05750719

Reaction notes

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