Hydrochloric Acid → 3-Bromo-8-(2,6-dichloro-3-nitrobenzyloxy)-2-methylimidazo[1,2-a]pyridine hydrochloride

HRID 1290201Notes

Reaction equation

HRID 1290201 reaction equation
[Br:1][C:2]1[N:6]2[CH:7]=[CH:8][CH:9]=[C:10]([O:11][CH2:12][C:13]3[C:18]([Cl:19])=[CH:17][CH:16]=[C:15]([N+:20]([O-:22])=[O:21])[C:14]=3[Cl:23])[C:5]2=[N:4][C:3]=1[CH3:24].Cl>C(O)C>[ClH:19].[Br:1][C:2]1[N:6]2[CH:7]=[CH:8][CH:9]=[C:10]([O:11][CH2:12][C:13]3[C:18]([Cl:19])=[CH:17][CH:16]=[C:15]([N+:20]([O-:22])=[O:21])[C:14]=3[Cl:23])[C:5]2=[N:4][C:3]=1[CH3:24]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 117969163-Bromo-8-(2,6-dichloro-3-nitrobenzyloxy)-2-methylimidazo[1,2-a]pyridine

Product 1

HCID 189232323-Bromo-8-(2,6-dichloro-3-nitrobenzyloxy)-2-methylimidazo[1,2-a]pyridine hydrochlorideYield 161.4%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

To a suspension of 3-bromo-8-(2,6-dichloro-3-nitrobenzyloxy)-2-methylimidazo[1,2-a]pyridine (200 mg) in ethanol (2 ml) was added hydrogen chloride in ethanol (3.5 Mol solution, 1 ml). The solution was concentrated to half volume under reduced pressure. The separated precipitates were collected by filtration and washed with ethanol to give 3-bromo-8-(2,6-dichloro-3-nitrobenzyloxy)-2-methylimidazo[1,2-a]pyridine hydrochloride (175 mg) as an off-white solid.

Workup

  1. concentrationThe solution was concentrated to half volume under reduced pressure
  2. customThe separated precipitates
  3. filtrationwere collected by filtration
  4. washwashed with ethanol

Sources & evidence

ORD record
ord-d4ac2012b2d24e31a6246127afc9be8d
Source dataset
uspto-grants-1998_05
Patent number
US05750699

Reaction notes

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