HCID 10717796, compound → HCID 10836601, compound

HRID 1290234Notes

Reaction equation

HRID 1290234 reaction equation
[CH3:1][C:2]1[C:3]([CH:7]([C:9]2[N:10]=[CH:11][N:12]([C:14]([C:27]3[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=3)([C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)[C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)[CH:13]=2)[OH:8])=[CH:4][S:5][CH:6]=1>C(Cl)Cl.O=[Mn]=O>[CH3:1][C:2]1[C:3]([C:7]([C:9]2[N:10]=[CH:11][N:12]([C:14]([C:27]3[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=3)([C:15]3[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=3)[C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)[CH:13]=2)=[O:8])=[CH:4][S:5][CH:6]=1

Participants

4

Reactant 1

HCID 10717796HCID 10717796, compound

Product 1

HCID 10836601HCID 10836601, compound

Reagents, catalysts & solvents 2

HCID 14801Manganese dioxideCatalystHCID 6344DichloromethaneSolvent

Procedure

To a solution of (4-methylthien-3-yl)-1-trityl-imidazol-4-yl-methanol, B2, (6.5 g, 14.9 mmol) in 100 mL of CH2Cl2 was added MnO2 (13 g). The mixture was stirred at room temperature for 3 hr and then filtered through Dicalite and the solvent was evaporated in vacuo to give (4-methylthien-3-yl)-1-trityl-imidazol-4-yl-methanone, A3. 1H NMR (CDCl3) supported the assigned structure. ##STR41##

Workup

  1. filtrationfiltered through Dicalite
  2. customthe solvent was evaporated in vacuo

Sources & evidence

ORD record
ord-daadefd55cfe431697b47e225d6a686b
Source dataset
uspto-grants-1998_05
Patent number
US05750720

Reaction notes

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