Testosterone → HCID 11121164, compound

Participants

Reaction Steps

By the method of example 1, testosterone (2.88 g, 10 mM), potassium tert-butoxide (3.40 g, 30 mM) and iso- propylnitrate (1.01 ml) are reacted to yield 17β-hydroxy-4-nitroandrost-4-en-3-one, m.p. 158°-160° C. (acetone-hexane) IR 3533, 1689, 1615(m), 1635 cm-1MS(CI) 334(100%, M+l), 316(50%, M+1-H2 0) 1H-NMR 6 (CDC13) 0.80(3H, S, C1 8-Me), 1.30(s, Clg-Me), 3.66(lH, t, C17 -H). This compound has the following structure: ##STR11##

Provenance & Evidence