反应详情

To a 0° C. solution, under argon, of 0.580 g of product from Example 323 in 10 ml of pyridine is added 0.430 g of p-toluenesulfonyl chloride. The reaction is stirred at room temperature overnight. The mixture is quenched with water, extracted with diethyl ether, washed with water and saturated sodium chloride, dried and concentrated in vacuo. The residue is purified by chromatography (Silica gel: 50% ethyl acetate/hexane) to give 0.520 g of the desired product.

1. customThe mixture is quenched with water
2. extractionextracted with diethyl ether
3. washwashed with water and saturated sodium chloride
4. customdried
5. concentrationconcentrated in vacuo
6. customThe residue is purified by chromatography (Silica gel: 50% ethyl acetate/hexane)