Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Chloride | HCID 5234 | — |
| Reactant | Chloromethyl ethyl ether | HCID 18523 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Monobasic potassium phosphate | HCID 516951 | — |
| Reactant | HCID 86179986 | HCID 86179986 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 131720651 | HCID 131720651 | 46.5% |
Reaction Steps
To a 0° C. mixture of 0.165 g of product from Example 383 in 4 ml of tetrahydrofuran and 0.222 g of diisopropylethyl amine is added 0.122 g of chloromethylethyl ether. The reaction is stirred for 45 minutes at 0° C. and then 23 hours at 20° C. The mixture is given an aqueous workup (ethyl acetate, 0.5M potassium dihydrogen phosphate, saturated sodium chloride) and the purified by chromatography to give 0.100 g of the desired product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05750735 |
|---|
| Source dataset | uspto-grants-1998_05 |
|---|
| ORD ID | ord-1a8a49a04ca3471e9cca6d0f58f7286e |
|---|
| Source note | uspto-grants-1998_05 |
|---|
