Sodium Chloride → HCID 131720651, compound

HRID 1290445Notes

Reaction equation

HRID 1290445 reaction equation
[OH:1][CH2:2][CH:3]1[S:7][CH:6]([S:8][C:9](=[O:11])[CH3:10])[CH2:5][CH2:4]1.C(N(C(C)C)CC)(C)C.Cl[CH2:22][O:23][CH2:24][CH3:25].P([O-])(O)(O)=O.[K+].[Cl-].[Na+]>O1CCCC1.C(OCC)(=O)C>[CH2:24]([O:23][CH2:22][O:1][CH2:2][C@@H:3]1[S:7][CH:6]([S:8][C:9](=[O:11])[CH3:10])[CH2:5][CH2:4]1)[CH3:25]

Participants

8

Reactant 5

HCID 5234Sodium ChlorideHCID 18523Chloromethyl ethyl etherHCID 81531DiisopropylethylamineHCID 516951Monobasic potassium phosphateHCID 86179986HCID 86179986, compound

Product 1

HCID 131720651HCID 131720651, compoundYield 46.5%

Reagents, catalysts & solvents 2

HCID 8028TetrahydrofuranSolventHCID 8857Ethyl AcetateSolvent

Conditions

Temperature
0 °C

Procedure

To a 0° C. mixture of 0.165 g of product from Example 383 in 4 ml of tetrahydrofuran and 0.222 g of diisopropylethyl amine is added 0.122 g of chloromethylethyl ether. The reaction is stirred for 45 minutes at 0° C. and then 23 hours at 20° C. The mixture is given an aqueous workup (ethyl acetate, 0.5M potassium dihydrogen phosphate, saturated sodium chloride) and the purified by chromatography to give 0.100 g of the desired product.

Workup

  1. custom23 hours
  2. customat 20° C
  3. customthe purified by chromatography

Sources & evidence

ORD record
ord-1a8a49a04ca3471e9cca6d0f58f7286e
Source dataset
uspto-grants-1998_05
Patent number
US05750735

Reaction notes

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