Water → HCID 12159128, compound

HRID 1290457Notes

Reaction equation

HRID 1290457 reaction equation
[NH2:1][CH:2]([CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)[CH:3]=[CH2:4].[C:12](=[O:15])([O-])[O-].[Na+].[Na+].[OH2:18]>O1CCCC1>[C:12]1(=[O:15])[N:1]([CH:2]([CH2:5][C:6]2[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=2)[CH:3]=[CH2:4])[C:5](=[O:18])[C:6]2=[CH:11][CH:10]=[CH:9][CH:8]=[C:7]12

Participants

5

Reactant 3

HCID 962WaterHCID 10340Sodium CarbonateHCID 19973227HCID 19973227, compound

Product 1

HCID 12159128HCID 12159128, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

(RS)-3-Amino-4-phenyl-1-butene (1.2 g, 8.0 mmol) was dissolved in tetrahydrofuran (20 ml). To the solution, a solution of N-carbethoxyphthalimido (2.2 g, 10.0 mmol) in water (20 ml) and anhydrous sodium carbonate (1.06 g, 10.0 mmol) was added and stirred at room temperature for 1 hour. The reaction mixture was concentrated under reduced pressure to remove tetrahydrofuran, followed by extraction with ethyl acetate.

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. customto remove tetrahydrofuran
  3. extractionfollowed by extraction with ethyl acetate

Sources & evidence

ORD record
ord-9000de3c507d4cefbc304809a3e2fb2f
Source dataset
uspto-grants-1998_05
Patent number
US05750717

Reaction notes

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