反应详情

A suspension of the product of Example 1 (100 mg) in a 33% w/v solution of methylamine in ethanol (3 ml) was stirred for 18 hours. The solid formed, after filtration and washing with a little ethyl acetate, gave the title compound, 65 mg: m.p. 169°-171° C.; NMR (d6 DMSO)δ8.14(2H,d), 8.06(1H,bq), 8.00(2H,d), 7.05(2H,d), 6.80(2H,d), 4.56(2H,s), 3.82(2H,s), 3.30(4H,t), 2.66(3H,d), 2.61(4H,t); m/e 369 (M+H)+ ; calculated for C20H24N4O3 : C, 65.2; H, 6.6; N, 15.2. found: C, 65.0; H, 6.8; N, 15.1%.

1. customThe solid formed
2. filtrationafter filtration
3. washwashing with a little ethyl acetate