反应详情

A mixture of acetic acid (200 mL) and 2-aminosulfonyl-6-sec-butyl-4-methoxy-N,N-diethylbenzamide. (51.7 g) was refluxed overnight. The acetic acid was removed by distillation, the residue was poured into ice/2M NaOH (80 mL). The aqueous solution was washed with CH2Cl2, acidified with concentrated HCl and the precipitate which formed was collected by filtration to afford 4-sec-butyl-6-methoxysaccharin.

1. temperature(51.7 g) was refluxed overnight
2. customThe acetic acid was removed by distillation
3. additionthe residue was poured into ice/2M NaOH (80 mL)
4. washThe aqueous solution was washed with CH2Cl2
5. customthe precipitate which formed
6. filtrationwas collected by filtration