2-aminosulfonyl-6-sec-butyl-4-methoxy-N,N-diethylbenzamide → 4-Sec-butyl-6-methoxysaccharin

Participants

Reaction Steps

A mixture of acetic acid (200 mL) and 2-aminosulfonyl-6-sec-butyl-4-methoxy-N,N-diethylbenzamide. (51.7 g) was refluxed overnight. The acetic acid was removed by distillation, the residue was poured into ice/2M NaOH (80 mL). The aqueous solution was washed with CH2Cl2, acidified with concentrated HCl and the precipitate which formed was collected by filtration to afford 4-sec-butyl-6-methoxysaccharin.

Provenance & Evidence