反应详情

To a solution of 1-(4-aminophenyl)-4-(4-pyridyl)piperazine (100 mg) in DMF (8ml) was added succinic anhydride (79 mg). The reaction mixture was stirred at room temperature for 2.5 hr and a precipitate was collected, washed with DMF and ethanol, then dried to give the title compound (106 mg) as a beige-coloured solid: m.p. 263°-264° C.; NMR (d6DMSO+CF3CO2H) δ 2.68(4H,m), 3.80(4H,m, 4.19(4H,m), 7.20(2H,d), 7.56(2H,d), 7.82(2H,d), 8.21(2H,d), 9.62(1H,s); m/Z 355 (M+H)+ ; calculated for C19H22N4O3. 0.4 H2O: C, 63.1%; H, 6.36%; N, 15.5%; found: C, 63.1%; H, 6.4%; N, 15.7%.

1. customa precipitate was collected
2. washwashed with DMF and ethanol
3. customdried