HCID 18918291, compound → HCID 18918242, compound

HRID 1290544Notes

Reaction equation

HRID 1290544 reaction equation
OCC(C1C=CC=CC=1)CC(OCC)=O.C[O:17][C:18](=[O:47])[CH2:19][CH:20]([C:41]1[CH:46]=[CH:45][CH:44]=[CH:43][CH:42]=1)[CH2:21][O:22][C:23]1[CH:28]=[CH:27][C:26]([N:29]2[CH2:34][CH2:33][N:32]([C:35]3[CH:40]=[CH:39][N:38]=[CH:37][CH:36]=3)[CH2:31][CH2:30]2)=[CH:25][CH:24]=1>>[C:41]1([CH:20]([CH2:21][O:22][C:23]2[CH:24]=[CH:25][C:26]([N:29]3[CH2:30][CH2:31][N:32]([C:35]4[CH:36]=[CH:37][N:38]=[CH:39][CH:40]=4)[CH2:33][CH2:34]3)=[CH:27][CH:28]=2)[CH2:19][C:18]([OH:47])=[O:17])[CH:46]=[CH:45][CH:44]=[CH:43][CH:42]=1

Participants

3

Reactant 2

HCID 18918291HCID 18918291, compoundHCID 18918601HCID 18918601, compound

Product 1

HCID 18918242HCID 18918242, compoundYield 10%

Procedure

In a similar manner to Example 204ii), but starting from RS ethyl 4-hydroxy-3-phenylbutyrate was made RS methyl-3-phenyl-4-[4-[4-(4-pyridyl)piperazin-1-yl]phenoxy]butyrate in 10% yield as an oil; NMR (d6DMSO+CD3COOD) δ 8.23(2H,d), 7.3(5H,m), 7.17(2H,d), 6.95(2H,d), 6.83(2H,d), 4.06(2H,m), 3.77(4H,t), 3.55(3H,s), 3.51(1H,m), 3.17(4H, t), 2.83(2H,m); m/e 432(M+H)+.

Sources & evidence

ORD record
ord-fc4d1592158f4e1996ce5f50babfad03
Source dataset
uspto-grants-1998_05
Patent number
US05750754

Reaction notes

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