HCID 18918291, compound → HCID 18918242, compound

Participants

Reaction Steps

In a similar manner to Example 204ii), but starting from RS ethyl 4-hydroxy-3-phenylbutyrate was made RS methyl-3-phenyl-4-[4-[4-(4-pyridyl)piperazin-1-yl]phenoxy]butyrate in 10% yield as an oil; NMR (d6DMSO+CD3COOD) δ 8.23(2H,d), 7.3(5H,m), 7.17(2H,d), 6.95(2H,d), 6.83(2H,d), 4.06(2H,m), 3.77(4H,t), 3.55(3H,s), 3.51(1H,m), 3.17(4H, t), 2.83(2H,m); m/e 432(M+H)+.

Provenance & Evidence