Acetyl chloride → HCID 18916382, compound

HRID 1290643Notes

Reaction equation

HRID 1290643 reaction equation
[NH2:1][C:2]1[O:3][C:4]2[C:10]([N:11]3[C:16](=[O:17])[CH:15]=[C:14]([C:18]([F:21])([F:20])[F:19])[N:13]([CH3:22])[C:12]3=[O:23])=[C:9]([F:24])[CH:8]=[C:7]([Cl:25])[C:5]=2[N:6]=1.[C:26](Cl)(=[O:28])[CH3:27]>N1C=CC=CC=1>[C:26]([NH:1][C:2]1[O:3][C:4]2[C:10]([N:11]3[C:16](=[O:17])[CH:15]=[C:14]([C:18]([F:20])([F:21])[F:19])[N:13]([CH3:22])[C:12]3=[O:23])=[C:9]([F:24])[CH:8]=[C:7]([Cl:25])[C:5]=2[N:6]=1)(=[O:28])[CH3:27]

Participants

4

Reactant 2

HCID 6367Acetyl chlorideHCID 18916387HCID 18916387, compound

Product 1

HCID 18916382HCID 18916382, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

A solution of 3.8 grams (10 mmole) of 3-(2-amino-4-chloro-6-fluorobenzoxazol-7-yl)-1-methyl-6-trifluoromethyl-2,4-(1H,3H)pyrimidinedione and 1.0 gram (15 mmole) of acetyl chloride in 20 mL of pyridine is stirred at ambient temperature for about 18 hours. The reaction mixture is concentrated under reduced pressure, yielding 3-(2-acetylamino-4-chloro-6-fluorobenzoxazol-7-yl)-1-methyl-6-trifluoromethyl-2,4-(1H,3H)pyrimidinedione.

Workup

  1. concentrationThe reaction mixture is concentrated under reduced pressure

Sources & evidence

ORD record
ord-e6a9c768c8294d17aef76904e2379d44
Source dataset
uspto-grants-1998_05
Patent number
US05753595

Reaction notes

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