HCID 18916416, compound → HCID 18916425, compound

HRID 1290645Notes

Reaction equation

HRID 1290645 reaction equation
C([N:4]([C:9]1[O:10][C:11]2[C:17]([N:18]3[C:23](=[O:24])[CH:22]=[C:21]([C:25]([F:28])([F:27])[F:26])[N:20]([CH3:29])[C:19]3=[O:30])=[C:16]([F:31])[CH:15]=[C:14]([Cl:32])[C:12]=2[N:13]=1)[S:5]([CH3:8])(=[O:7])=[O:6])(=O)C>NN>[CH3:8][S:5]([NH:4][C:9]1[O:10][C:11]2[C:17]([N:18]3[C:23](=[O:24])[CH:22]=[C:21]([C:25]([F:26])([F:28])[F:27])[N:20]([CH3:29])[C:19]3=[O:30])=[C:16]([F:31])[CH:15]=[C:14]([Cl:32])[C:12]=2[N:13]=1)(=[O:7])=[O:6]

Participants

3

Reactant 1

HCID 18916416HCID 18916416, compound

Product 1

HCID 18916425HCID 18916425, compound

Reagents, catalysts & solvents 1

HCID 9321HydrazineSolvent

Procedure

A stirred solution of 4.5 grams (10 mmole) of 3-[2-(N-acetyl-N-methylsulfonylamino)-4-chloro-6-fluorobenzoxazol-7-yl]-1-methyl-6-trifluoromethyl-2,4-(1H,3H)pyrimidinedione in 25 mL of 85% hydrazine is heated to 60° C., where it stirs for about 18 hours. After this time the reaction mixture is concentrated under reduced pressure, yielding 3-(2-methylsulfonylamino-4-chloro-6-fluorobenzoxazol-7-yl)-1-methyl-6-trifluoromethyl-2,4-(1H,3H)-pyrimidinedione.

Workup

  1. concentrationAfter this time the reaction mixture is concentrated under reduced pressure

Sources & evidence

ORD record
ord-db7ed624a70540189008e6b6b0020f7e
Source dataset
uspto-grants-1998_05
Patent number
US05753595

Reaction notes

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