HCID 18916416, compound → HCID 18916425, compound

Participants

Reaction Steps

A stirred solution of 4.5 grams (10 mmole) of 3-[2-(N-acetyl-N-methylsulfonylamino)-4-chloro-6-fluorobenzoxazol-7-yl]-1-methyl-6-trifluoromethyl-2,4-(1H,3H)pyrimidinedione in 25 mL of 85% hydrazine is heated to 60° C., where it stirs for about 18 hours. After this time the reaction mixture is concentrated under reduced pressure, yielding 3-(2-methylsulfonylamino-4-chloro-6-fluorobenzoxazol-7-yl)-1-methyl-6-trifluoromethyl-2,4-(1H,3H)-pyrimidinedione.

Provenance & Evidence