Methyl iodide → HCID 18916393, compound

HRID 1290646Notes

Reaction equation

HRID 1290646 reaction equation
[CH3:1][S:2]([NH:5][C:6]1[O:7][C:8]2[C:14]([N:15]3[C:20](=[O:21])[CH:19]=[C:18]([C:22]([F:25])([F:24])[F:23])[N:17]([CH3:26])[C:16]3=[O:27])=[C:13]([F:28])[CH:12]=[C:11]([Cl:29])[C:9]=2[N:10]=1)(=[O:4])=[O:3].[C:30](=O)([O-])[O-].[K+].[K+].CI>CC(C)=O>[CH3:30][N:5]([C:6]1[O:7][C:8]2[C:14]([N:15]3[C:20](=[O:21])[CH:19]=[C:18]([C:22]([F:24])([F:23])[F:25])[N:17]([CH3:26])[C:16]3=[O:27])=[C:13]([F:28])[CH:12]=[C:11]([Cl:29])[C:9]=2[N:10]=1)[S:2]([CH3:1])(=[O:4])=[O:3]

Participants

5

Reactant 3

HCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 18916425HCID 18916425, compound

Product 1

HCID 18916393HCID 18916393, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

This compound is prepared in the manner of Step F, Example 1, with 4.3 grams (10 mmole) of 3-(2-methylsulfonylamino-4-chloro-6-fluorobenzoxazol-7-yl)-1-methyl-6-trifluoromethyl-2,4-(1H,3H)pyrimidinedione, 1.5 grams (11 mmole) of potassium carbonate, 1.7 grams (12 mmole) of methyl iodide, and 25 mL of acetone as reagents.

Sources & evidence

ORD record
ord-262b615cfbc146b881b9951e5c07c40d
Source dataset
uspto-grants-1998_05
Patent number
US05753595

Reaction notes

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