反应详情

Octahydro-1-methyl-1-pyrindine-6,6-diphosphonic acid (0.12 mmol) is dissolved in a mixture of water (25 ml) and DMSO (5 ml). To this is added 2-acetylthioethyl bromide (0.60 mmol) and the reaction mixture is heated at 60° for 24 hours. The reaction mixture is cooled, treated with charcoal, filtered and concentrated under reduced pressure. The crude residue is triturated with diethylether and the product can be obtained by recrystallizing the solid residue in water and isopropanol.

1. temperaturethe reaction mixture is heated at 60° for 24 hours
2. temperatureThe reaction mixture is cooled
3. filtrationfiltered
4. concentrationconcentrated under reduced pressure
5. customThe crude residue is triturated with diethylether
6. customthe product can be obtained
7. customby recrystallizing the solid residue in water