Cesium carbonate → 2-Methylthio-4-chloro-5-nitro-6-(3-dimethylaminocarbonylphenoxy)pyrimidine

HRID 1290666노트

반응식

HRID 1290666 반응식
[CH3:1][S:2][C:3]1[N:8]=[C:7](Cl)[C:6]([N+:10]([O-:12])=[O:11])=[C:5]([Cl:13])[N:4]=1.[CH3:14][N:15]([CH3:25])[C:16]([C:18]1[CH:19]=[C:20]([OH:24])[CH:21]=[CH:22][CH:23]=1)=[O:17].C(=O)([O-])[O-].[Cs+].[Cs+]>>[CH3:1][S:2][C:3]1[N:4]=[C:5]([Cl:13])[C:6]([N+:10]([O-:12])=[O:11])=[C:7]([O:24][C:20]2[CH:21]=[CH:22][CH:23]=[C:18]([C:16]([N:15]([CH3:25])[CH3:14])=[O:17])[CH:19]=2)[N:8]=1

참가 물질

4

반응물 3

HCID 10796Cesium carbonateHCID 6375243-hydroxy-N,N-dimethylbenzamideHCID 113454584,6-Dichloro-2-(methylthio)-5-nitropyrimidine

생성물 1

HCID 221026862-Methylthio-4-chloro-5-nitro-6-(3-dimethylaminocarbonylphenoxy)pyrimidine

실험 절차

In a similar manner, 2-methylthio-5-nitro-4,6-dichloropyrimidine was treated with 3-(dimethylaminocarbonyl)phenol in the presence of cesium carbonate to afford 2-methylthio-5-nitro-4-chloro-6-(3-dimethylaminocarbonylphenoxy)pyrimidine, a compound of formula (M).

출처 및 근거

ORD 기록
ord-37f73696a95e4b3aae298dd2aa83f2de
출처 데이터셋
uspto-grants-1998_05
특허 번호
US05753635

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