Phenyl isocyanate → HCID 18918117, compound

HRID 1290729Notes

Reaction equation

HRID 1290729 reaction equation
[NH2:1][CH2:2][CH:3]1[O:8][CH2:7][CH2:6][N:5]([CH2:9][C:10]2[CH:15]=[CH:14][C:13]([F:16])=[CH:12][CH:11]=2)[CH2:4]1.[C:17]1([N:23]=[C:24]=[O:25])[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>CN(C)C=O>[F:16][C:13]1[CH:14]=[CH:15][C:10]([CH2:9][N:5]2[CH2:6][CH2:7][O:8][CH:3]([CH2:2][NH:1][C:24]([NH:23][C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)=[O:25])[CH2:4]2)=[CH:11][CH:12]=1

Participants

4

Reactant 2

HCID 7672Phenyl isocyanateHCID 102427352-Aminomethyl-4-(4-fluorobenzyl)morpholine

Product 1

HCID 18918117HCID 18918117, compoundYield 72%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

To a solution of 2-aminomethyl-4-(p-fluorobenzyl)-morpholine (1.0 g, 4.5 mmol) in dimethylformamide (10 ml) was added under ice-cooling phenyl isocyanate (0.53 ml, 4.9 mmol) and the mixture was stirred for 30 minutes. To the reaction mixture was added purified water (20 ml) and the crystals thus separated out were then recovered by filtration to give the title compound (1.1 g). Yield=72%.

Workup

  1. additionTo the reaction mixture was added
  2. custompurified water (20 ml)
  3. customthe crystals thus separated out
  4. filtrationwere then recovered by filtration

Sources & evidence

ORD record
ord-f8d06e850ca74ef898e89535fc0ba8e6
Source dataset
uspto-grants-1998_05
Patent number
US05753654

Reaction notes

Loading…