Hydrochloric Acid → HCID 9848511, compound

Participants

Reaction Steps

A mixture of 2.15 g of 1-ethyl-6,8-difluoro-1,4-dihydro-4-oxo-7-[4-(4-acetamidobenzenesulfonyl)-1-piperazinyl]-3-quinolinecarboxylic acid obtained in Example 1, 100 ml of 2N hydrochloric acid and 50 ml of ethanol is refluxed for 2 hours while stirring. The reaction mixture is then concentrated under reduced pressure. To the residue is added 1N sodium hydroxide solution to dissolve. The pH of the solution is adjusted to 7.0 with acetic acid.

Provenance & Evidence