Hydrochloric Acid → HCID 9848511, compound

HRID 1290732Notes

Reaction equation

HRID 1290732 reaction equation
[CH2:1]([N:3]1[C:12]2[C:7](=[CH:8][C:9]([F:33])=[C:10]([N:14]3[CH2:19][CH2:18][N:17]([S:20]([C:23]4[CH:28]=[CH:27][C:26]([NH:29]C(=O)C)=[CH:25][CH:24]=4)(=[O:22])=[O:21])[CH2:16][CH2:15]3)[C:11]=2[F:13])[C:6](=[O:34])[C:5]([C:35]([OH:37])=[O:36])=[CH:4]1)[CH3:2].Cl>C(O)C>[CH2:1]([N:3]1[C:12]2[C:7](=[CH:8][C:9]([F:33])=[C:10]([N:14]3[CH2:19][CH2:18][N:17]([S:20]([C:23]4[CH:24]=[CH:25][C:26]([NH2:29])=[CH:27][CH:28]=4)(=[O:22])=[O:21])[CH2:16][CH2:15]3)[C:11]=2[F:13])[C:6](=[O:34])[C:5]([C:35]([OH:37])=[O:36])=[CH:4]1)[CH3:2]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 18918200HCID 18918200, compound

Product 1

HCID 9848511HCID 9848511, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 2.15 g of 1-ethyl-6,8-difluoro-1,4-dihydro-4-oxo-7-[4-(4-acetamidobenzenesulfonyl)-1-piperazinyl]-3-quinolinecarboxylic acid obtained in Example 1, 100 ml of 2N hydrochloric acid and 50 ml of ethanol is refluxed for 2 hours while stirring. The reaction mixture is then concentrated under reduced pressure. To the residue is added 1N sodium hydroxide solution to dissolve. The pH of the solution is adjusted to 7.0 with acetic acid.

Workup

  1. temperatureis refluxed for 2 hours
  2. concentrationThe reaction mixture is then concentrated under reduced pressure
  3. additionTo the residue is added 1N sodium hydroxide solution
  4. dissolutionto dissolve

Sources & evidence

ORD record
ord-6e5cb86a5d8e46b0b465c67444237e67
Source dataset
uspto-grants-1998_05
Patent number
US05753658

Reaction notes

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