HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isopropylamine → HCID 54508459, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isopropylamine | HCID 6363 | — |
| Reactant | Methanaminium, N-((1H-benzotriazol-1-yloxy)(dimethylamino)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 2733084 | — |
| Reactant | HCID 86747359 | HCID 86747359 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 54508459 | HCID 54508459 | 84.9% |
Reaction Steps
A solution of 33.5 mg of (S)-1-[[(2S,3S)-3-hexyl-4-oxo-2-oxetanyl]methyl]dodecyl hydrogen malonate (Example N) in 2 ml of acetonitrile was treated with 60 mg of HBTU and 75 mg of isopropylamine. After stirring the reaction mixture was filtered, the filtrate was concentrated and the residue was chromatographed on silica gel with hexane/methylene chloride/ethyl acetate (2:2:1). There were obtained 31.1 mg of (S)-1-[[(2S, 3S)-3-hexyl-4-oxo-2-oxetanyl]methyl]dodecyl-N-isopropylmalonamate, m.p. 59°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05466708 |
| Source dataset | uspto-grants-1995_11 |
| ORD ID | ord-a9541aae55594ec5aeebaf31b31a73d3 |
| Source note | uspto-grants-1995_11 |