Dimethylformamide → HCID 18918155, compound

HRID 1290760Notes

Reaction equation

HRID 1290760 reaction equation
[NH:1]1[CH:5]=[CH:4][N:3]=[C:2]1[CH:6]=[C:7]1[C:19]2[N:18]3[CH:20]=[CH:21][N:22]=[C:17]3[C:16](=[O:23])[NH:15][C:14]=2[C:13]2[CH:12]=[CH:11][CH:10]=[CH:9][C:8]1=2.CN(C)C=O>[Pd].C(O)(=O)C>[NH:1]1[CH:5]=[CH:4][N:3]=[C:2]1[CH2:6][CH:7]1[C:19]2[N:18]3[CH:20]=[CH:21][N:22]=[C:17]3[C:16](=[O:23])[NH:15][C:14]=2[C:13]2[CH:12]=[CH:11][CH:10]=[CH:9][C:8]1=2

Participants

5

Reactant 2

HCID 6228DimethylformamideHCID 70345102HCID 70345102, compound

Product 1

HCID 18918155HCID 18918155, compoundYield 30.1%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 176Acetic AcidSolvent

Procedure

The procedure is performed as in Example 21, but starting with 1.65 g of 10-(2-imidazolylmethylene)-5H,10H-imidazo[1,2-a]indeno[1,2-e]pyrazin-4-one, 300 ml of dimethylformamide, 5 ml of acetic acid and 0.17 g of 10% palladium on charcoal. 0.5 g of 10-(2-imidazolylmethyl)-5H,10H-imidazo[1,2-a]indeno-[1,2-e]pyrazin-4-one is obtained, in the form of a pale yellow solid melting above 260° C. (Analysis % calculated C: 67.32, H: 4.32, N: 23.09, O: 5.27, % found C: 67.2, H: 4.3, N: 23.0).

Sources & evidence

ORD record
ord-29c4523622014ea09cc53f91fa51e6d0
Source dataset
uspto-grants-1998_05
Patent number
US05753657

Reaction notes

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