Dimethylformamide dimethyl acetal → HCID 4362726, compound

HRID 1290811Notes

Reaction equation

HRID 1290811 reaction equation
[Cl:1][C:2]1[CH:13]=[C:12]([Cl:14])[CH:11]=[CH:10][C:3]=1[O:4][CH:5]([CH3:9])[C:6](=[O:8])[CH3:7].CO[CH:17](OC)[N:18]([CH3:20])[CH3:19]>CO>[Cl:1][C:2]1[CH:13]=[C:12]([Cl:14])[CH:11]=[CH:10][C:3]=1[O:4][CH:5]([CH3:9])[C:6](=[O:8])[CH:7]=[CH:17][N:18]([CH3:20])[CH3:19]

Participants

4

Reactant 2

HCID 78373Dimethylformamide dimethyl acetalHCID 37655463-(2,4-Dichlorophenoxy)butan-2-one

Product 1

HCID 4362726HCID 4362726, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
120 °C

Procedure

A mixture of 3-(2,4-dichlorophenoxy)-2-butanone (4.66 g) and N,N-dimethylformamide dimethylacetal (2.38 g) was heated under argon in an oil bath at 120° C. for 11 hours. The methanol produced in the reaction was removed under reduced pressure and the residue was triturated with n-hexane. The solid was collected by filtration and washed with cold diethyl ether to give 4-(2,4-dichlorophenoxy)-1-(dimethylamino)-1-penten-3-one. Yield 4.07 g.

Workup

  1. customwas removed under reduced pressure
  2. customthe residue was triturated with n-hexane
  3. filtrationThe solid was collected by filtration
  4. washwashed with cold diethyl ether

Sources & evidence

ORD record
ord-90ba88305cb84c3ca3f2ba1d40e73973
Source dataset
uspto-grants-1998_05
Patent number
US05753665

Reaction notes

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