反应详情

Anhydrous aluminium chloride (27.2 g) was added to a stirred solution of 2-methylpropionyl chloride (23.4 g) in dry trichloromethane (100 ml) with external cooling to between 0° C. and 15° C. Over a period of 1 hour chloroethene (20 g) was passed through the mixture held at 24°-26° C., after which stirring was continued for a further 40 minutes. The reaction mixture was then poured onto crushed ice, the organic layer was separated, dried over magnesium sulphate and distilled under reduced pressure to obtain a colourless liquid of 1,1-dichloro-4-methyl-3-pentanone. Yield 23 g.

1. temperaturewith external cooling to between 0° C. and 15° C
2. customheld at 24°-26° C.
3. additionThe reaction mixture was then poured
4. customonto crushed ice
5. customthe organic layer was separated
6. dry with materialdried over magnesium sulphate
7. distillationdistilled under reduced pressure