4-Chlorophenol → HCID 18919357, compound

A solution of 3-chloro-2-pentanone (10 g) in acetone (50 ml) was added dropwise to a stirred mixture of 4-chlorophenol (11 g), potassium bicarbonate (20 g) and potassium iodide (1 g) in acetone (100 ml). After the addition was completed the mixture was heated under reflux for 6 hours. The mixture was then filtered, washed with acetone and the acetone was evaporated under reduced pressure. The residue was dissolved in ether (150 ml), and the ethereal mixture was washed with 300 ml of a 10% aqueous solution of sodium hydroxide followed by 300 ml of water. The mixture was then dried over magnesium sulphate. The solvent was evaporated and the residue was distilled under reduced pressure to give 3-(4-chlorophenoxy)-2-pentanone (10.96 g).

1. additionAfter the addition
2. temperaturewas heated
3. temperatureunder reflux for 6 hours
4. filtrationThe mixture was then filtered
5. washwashed with acetone
6. customthe acetone was evaporated under reduced pressure
7. dissolutionThe residue was dissolved in ether (150 ml)
8. washthe ethereal mixture was washed with 300 ml of a 10% aqueous solution of sodium hydroxide
9. dry with materialThe mixture was then dried over magnesium sulphate
10. customThe solvent was evaporated
11. distillationthe residue was distilled under reduced pressure

ORD record

ord-d8eb8299a8eb4ee096bf12b7af8327df

Source dataset

uspto-grants-1998_05

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US05753665