反应详情

A mixture of 1-(1,2,4-triazolo[1,5-a]pyrimidin-7-yl)ethyl benzoate (1 g), potassium carbonate (2 g), methanol (25 ml) and water (20 ml) was stirred at ambient temperature for 1 hour 30 minutes. The methanol was removed from the mixture under reduced pressure and the mixture was then diluted with brine (20 ml) before being continuously extracted with dichloromethane overnight. The extracts were dried over magnesium sulphate and the solvent evaporated under reduced pressure to give 1-(1,2,4-triazolo[1,5-a]pyrimidin-7-yl)ethanol. Yield 0.39 g.

1. customThe methanol was removed from the mixture under reduced pressure
2. additionthe mixture was then diluted with brine (20 ml)
3. extractionbefore being continuously extracted with dichloromethane overnight
4. dry with materialThe extracts were dried over magnesium sulphate
5. customthe solvent evaporated under reduced pressure