Trifluoroacetic acid → 4-[4-(2-Oxazolin-2-yl)benzylidene]piperidine

HRID 129086Notes

Reaction equation

[O:1]1[CH2:5][CH2:4][N:3]=[C:2]1[C:6]1[CH:18]=[CH:17][C:9]([CH2:10][CH:11]2[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]2)=[CH:8][CH:7]=1.C(OC(N1CCC(CC2C=CC(C3OCCN=3)=CC=2)CC1)=O)(C)(C)C.FC(F)(F)C(O)=O>>[O:1]1[CH2:5][CH2:4][N:3]=[C:2]1[C:6]1[CH:7]=[CH:8][C:9]([CH:10]=[C:11]2[CH2:12][CH2:13][NH:14][CH2:15][CH2:16]2)=[CH:17][CH:18]=1

Participants

Reactant 3

HCID 6422Trifluoroacetic acid

HCID 193726944-[4-(2-Oxazolin-2-yl)benzyl]piperidine

HCID 572576871-Tert.butoxycarbonyl-4-[4-(2-oxazolin-2-yl)benzyl]piperidine

Product 1

HCID 152314034-[4-(2-Oxazolin-2-yl)benzylidene]piperidine

Procedure

4-[4-(2-oxazolin-2-yl)benzyl]piperidine from 1-tert.butoxycarbonyl-4-[4-(2-oxazolin-2-yl)benzyl]piperidine and trifluoroacetic acid. Melting point: 110° C.

Sources & evidence

ORD record: ord-fe2912192080441780a794344c5d58a1
Source dataset: uspto-grants-1995_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05466687

Reaction notes

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