[2-(Propan-2-ylamino)phenyl]methanol → 2-((Propan-2-yl)amino)benzaldehyde

HRID 1290891Notes

Reaction equation

HRID 1290891 reaction equation
[CH:1]([NH:4][C:5]1[CH:12]=[CH:11][CH:10]=[CH:9][C:6]=1[CH2:7][OH:8])([CH3:3])[CH3:2]>C1(C)C=CC=CC=1.[O-2].[O-2].[Mn+4]>[CH:1]([NH:4][C:5]1[CH:12]=[CH:11][CH:10]=[CH:9][C:6]=1[CH:7]=[O:8])([CH3:3])[CH3:2]

Participants

4

Reactant 1

HCID 10797123[2-(Propan-2-ylamino)phenyl]methanol

Product 1

HCID 110410352-((Propan-2-yl)amino)benzaldehyde

Reagents, catalysts & solvents 2

HCID 178418406HCID 178418406, compoundCatalystHCID 1140TolueneSolvent

Procedure

While heating a solution of 40 g of 2-isopropylaminobenzyl alcohol in 200 ml toluene at 100° C., 58 g in total of activated manganese dioxide was added several times to the solution. After stirring at the same temperature for 30 minutes, insoluble matters were filtered off. The solvent was distilled off to give 2-isopropylaminobenzaldehyde.

Workup

  1. filtrationinsoluble matters were filtered off
  2. distillationThe solvent was distilled off

Sources & evidence

ORD record
ord-ce8f4cd759ae4e4f8d0ca8c3982018e6
Source dataset
uspto-grants-1998_05
Patent number
US05753673

Reaction notes

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