Thionyl Chloride → 1-Isopropyl-2-oxo-1,2-dihydro-3-quinolinecarbonyl chloride

HRID 1290896ノート

反応式

HRID 1290896 の反応式
[CH:1]([N:4]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[CH:7]=[C:6]([C:14](O)=[O:15])[C:5]1=[O:17])([CH3:3])[CH3:2].S(Cl)([Cl:20])=O>C1(C)C=CC=CC=1>[CH:1]([N:4]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[CH:7]=[C:6]([C:14]([Cl:20])=[O:15])[C:5]1=[O:17])([CH3:3])[CH3:2]

参加物

4

反応物 2

HCID 24386Thionyl ChlorideHCID 109442901-Isopropyl-2-oxo-1,2-dihydro-3-quinolinecarboxylic acid

生成物 1

HCID 154686831-Isopropyl-2-oxo-1,2-dihydro-3-quinolinecarbonyl chloride

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

A solution of 3.88 g of 1-isopropyl-2-oxo-1,2-dihydro-3-quinolinecarboxylic acid and 5.0 ml of thionyl chloride in 50 ml of toluene was stirred at 100° C. for 5 hours. After toluene was distilled off under vacuum, toluene was again added to the residue. The solvent was again distilled off under vacuum to give 4.22 g of 1-isopropyl-2-oxo-1,2-dihydro-3-quinolinecarbonyl chloride.

後処理

  1. distillationAfter toluene was distilled off under vacuum, toluene
  2. additionwas again added to the residue
  3. distillationThe solvent was again distilled off under vacuum

出典と根拠

ORDレコード
ord-d0f69c7de59b487981d6fbf30e0cf1df
出典データセット
uspto-grants-1998_05
特許番号
US05753673

反応ノート

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