反应详情

A solution of 3.88 g of 1-isopropyl-2-oxo-1,2-dihydro-3-quinolinecarboxylic acid and 5.0 ml of thionyl chloride in 50 ml of toluene was stirred at 100° C. for 5 hours. After toluene was distilled off under vacuum, toluene was again added to the residue. The solvent was again distilled off under vacuum to give 4.22 g of 1-isopropyl-2-oxo-1,2-dihydro-3-quinolinecarbonyl chloride.

1. distillationAfter toluene was distilled off under vacuum, toluene
2. additionwas again added to the residue
3. distillationThe solvent was again distilled off under vacuum