HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 1-Isopropyl-2-oxo-1,2-dihydro-3-quinolinecarbonyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 1-Isopropyl-2-oxo-1,2-dihydro-3-quinolinecarboxylic acid | HCID 10944290 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 1-Isopropyl-2-oxo-1,2-dihydro-3-quinolinecarbonyl chloride | HCID 15468683 | — |
Reaction Steps
A solution of 3.88 g of 1-isopropyl-2-oxo-1,2-dihydro-3-quinolinecarboxylic acid and 5.0 ml of thionyl chloride in 50 ml of toluene was stirred at 100° C. for 5 hours. After toluene was distilled off under vacuum, toluene was again added to the residue. The solvent was again distilled off under vacuum to give 4.22 g of 1-isopropyl-2-oxo-1,2-dihydro-3-quinolinecarbonyl chloride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05753673 |
| Source dataset | uspto-grants-1998_05 |
| ORD ID | ord-d0f69c7de59b487981d6fbf30e0cf1df |
| Source note | uspto-grants-1998_05 |