Thionyl Chloride → 3-Methylbenzo[b]thiophene-2-acetyl chloride
Reaction equation
[CH3:1][C:2]1[C:3]2[CH:14]=[CH:13][CH:12]=[CH:11][C:4]=2[S:5][C:6]=1[CH2:7][C:8](O)=[O:9].S(Cl)([Cl:17])=O>>[CH3:1][C:2]1[C:3]2[C:4](=[CH:11][CH:12]=[CH:13][CH:14]=2)[S:5][C:6]=1[CH2:7][C:8]([Cl:17])=[O:9]Participants
3
Procedure
A mixture of 2.0 g of 3-methylbenzo[b]thiophene-2-acetic acid and 19.4 ml of thionyl chloride is heated at reflux for 1 hour. The volatiles are evaporated in vacuo to give a residue which is concentrated from toluene three times and dried under vacuum to give 2.25 g of the desired product as a residue.
Workup
- temperatureis heated
- temperatureat reflux for 1 hour
- customThe volatiles are evaporated in vacuo
- customto give a residue which
- concentrationis concentrated from toluene three times
- customdried under vacuum
Sources & evidence
- ORD record
- ord-06a1fa68759541bebe33e831d133cd57
- Source dataset
- uspto-grants-1998_05
- Patent number
- US05753648
Reaction notes
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